Translation is the process of turning observations in the laboratory, clinic, and community into interventions that improve the health of individuals and the public — from diagnostics and therapeutics to medical procedures and behavioral changes.

The translational science spectrum (T1-T4) represents each stage of research along the path from the biological basis of health and disease to interventions that improve the health of individuals and the public. Each stage builds upon and informs the others. Patient involvement is a critical feature of all stages in translation.

T1 - the process of applying discoveries generated in preclinical laboratory research to experimental studies in primates and human participants

T2 - research allows investigators to extend limited clinical observations into controlled environments (e.g., phase III clinical trials) to establish evidence-based efficacy under optimal settings

T3 - investigators establish how specific prevention and treatment strategies work in real-world community settings (e.g., phase IV trials), assessing effectiveness, cost-effectiveness, and the influence on health practice. Important health agenda in the community needs to be translated back to the clinic and bench, respectively, to inform the processes of relevant application and basic discovery; these studies are considered as reverse T3 projects.

T4 - research involves the application of validated, health practices from communities to their impact on human populations. The latter is the ultimate pay-off for national and institutional investments into the translational research platform.

NIH Translational Science Fact Sheet

TRANSLATIONAL SCIENCE

Our mission at ACTSI is to rapidly and efficiently translate scientific discoveries to impact all populations of the Atlanta community through focused education and training, innovative support of discovery, and ethical community engagement. Translation is the process of turning observations in the laboratory, clinic, and community into interventions that improve the health of individuals and the public.

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Discovery

ACTSI Clinical Research Network (CRN) Infographic

The CRN provides a variety of resources including core lab service and bionutrition unit to support the research process. The program supports multiple sites across Georgia including Emory University, University of Georgia, Grady Health System,...

Discovery

New ACTSI Clinical Research Network (CRN) Fee Schedule

ACTSI’s CRN recently updated its initial fee schedule with new rates beginning June 1, 2017. Since 1960, the NIH provided funding for direct support of clinical research at Emory University Hospital. With the inception of the ACTSI in...